Identification and characterization of calcium sparks in cardiomyocytes derived from human induced pluripotent stem cells.
INTRODUCTION: Ca2+ spark constitutes the elementary units of cardiac excitation-contraction (E-C) coupling in mature cardiomyocytes.Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes are known to have electrophysiological properties similar to mature adult cardiomyocytes.However, it is unclear if they share similar calcium handling